The Vascular Surgery Scientist Training Program at Northwestern University is a two-year mentored research training experience for surgical residents (MD/DO) in general and vascular surgery and for PhD postdoctoral research fellows interested in vascular biology or vascular biomedical engineering careers, funded by a T32 grant from NIH. The T32 mechanism provides a stipend, tuition, fees for coursework, travel funds, and health insurance.
The key to this program is an individualized training plan developed by the mentor and trainee. The unique multidisciplinary environment provides trainees with opportunities to work with mentors from different disciplines. Our goal is to provide a seamless multidisciplinary environment in which the trainee may interact with a diverse group of distinguished research faculty. Trainees may select one of several tracks of study or a combination of tracks:
- Vascular biology with a basic science emphasis
- Clinical research including outcomes studies
- Biomedical devices in partnership with the Department of Biomedical Engineering
- An integrated program designed by the trainee and his/her mentors
Learn more about the training program below.
The following is a list of NU faculty who have agreed to serve as mentors for the Vascular Surgery Scientist Training Program along with brief descriptions of their areas of interest.
- Melina R. Kibbe, M.D,Division of Vascular Surgery, Department of Surgery: Dr. Kibbe’s research focuses on nitric oxide vascular biology. In addition, she is developing and evaluating nitric oxide-based pharmacological and bioengineering approaches to inhibit neointimal hyperplasia following vascular interventions. Her goal is to have a positive effect on patency rates of these procedures.http://kibbelab.northwestern.edu/
- Douglas E. Vaughan, MD, Division of Cardiology, Department of Medicine: Dr. Vaughan’s clinical interests include regenerative medicine, ischemic heart disease, lipid disorders, hypercoaguable states, artherosclerosis prevention, coronary artery disease, and acute coronary systems. For the last two decades, his laboratory has been involved in basic and preclinical investigations that have helped to define the molecular physiology of PAI-1 and its role in arterial thrombosis and arteriosclerosis, as well as the regenerative therapies for treating ischemic diseases. Moreover, the lab has performed numerous physiological and mechanistic clinical trials in humans that have identified key regulators of vascular fibrinolytic function and novel therapeutic approaches to reduce plasma PAI-1.
- Hossein Ardehali, MD, PhD, Division of Cardiology, Department of Medicine: Dr. Ardehali’s research interests include acute coronary syndromes, cardiology, coronary artery disease, heart disease, preventive cardiology, and cardiovascular diseases and genetics. His laboratory focuses on understanding the mechanism of myocardial cell death in response to ischemic damage. His lab is currently focusing on a mitochondrial protein called the mitochondrial ATP-binding cassette protein-1 (mABC1) and a serine/threonine kinase called Snf-1 relate kinase (SNRK). Dr. Ardehali was the first to show that mABC1 is protective against oxidant induced cell death in vitro.
- Amy S. Paller, MD, Department of Dermatology: Dr. Paller’s research interests include the biochemistry of lipids, skin cancer, cutaneous biology, pediatric dermatology, extracellular matrix, genetic skin disorders and signal transduction. Most recently, the Paller lab has been testing the role of gangliosides on wound healing. Using GM3 synthase knockout mice, the laboratory has reversed the wound healing defect of diabetic mice through activated EGFR and insulin signaling, and is looking at small molecules that deplete GM3 as a new therapy for diabetic wounds.
- Rosalind Ramsey-Goldman, MD, Division of Rheumatology, Department of Medicine: Dr. Ramsey-Goldman is currently thePI for the Patient-Oriented Clinical Research Program in Systemic Lupus Erythematosus (SLE), which examines risk factors to minimize complications related to SLE including osteoporosis, malignancy, and cardiovascular disease. In addition, she isactive in designing, monitoring, and performing clinical trials identifying novel biomarkers and testing innovative therapies for patients with SLE.
- Lonnie D. Shea, PhD, Department of Chemical and Biological Engineering: Dr. Shea’s interests focus on regenerative medicine, systems biology in gene and drug delivery, biomaterial, ovarian follicles, islet transplantation, nerve regeneration, and cancer models. He has over 14 years experience teaching chemical and biological engineering.
- Tsutomu Kume, PhD, Division of Cardiology, Department of Medicine, and Department of Molecular Pharmacology and Biological Chemistry: Dr. Kume’s research laboratory focuses on vascular formation and angiogenesis. A particular emphasis recently has been analysis of neovascularization in physiological and pathological settings using mice as a model system.
- William A. Muller, MD, PhD, Department of Pathology: Dr. Muller’s laboratory studies the inflammatory response at the cellular and molecular level. In particular, his laboratory focuses on the process of diapedesis, the "point of no return" in inflammation where leukocytes squeeze between tightly apposed endothelial cells to enter the site of inflammation. They have identified and cloned several molecules that are critical to the process of diapedesis, including PECAM (CD31), CD99, and VE-cadherin, and are studying how they regulate the inflammatory response using in vitro and in vivo models. Most recently, Dr. Muller has collaborated with Drs. Kibbe and Stupp to assess the ability of self-assembled nanofibers to migrate through endothelial monolayers.
- Joan M. Cook-Mills, PhD, Division of Allergy-Immunology, Department of Medicine: Dr. Cook-Mills laboratory has focused on regulation of inflammation by vascular cell adhesion molecule (VCAM-1). Dr. Cook-Mills is exploring pathways to block this signaling pathway in vivo to inhibit inflammation.
- Susan E. Quaggin, MD, Division of Nephrology, Department of Medicine, and Director of the Feinberg Cardiovascular Research Institute: Dr. Quaggin’s research program focuses on vascular biology, kidney development, and kidney disease. One of her major interests is on the genetic and molecular pathways that establish and maintain complex capillary structures, particularly those forming the renal glomerular filtration barrier. She also has a robust effort evaluating the role of stem cells in the vasculature.
- William H. Pearce, MD, Division of Vascular Surgery, Department of Surgery: Dr. Pearce has been actively involved in basic science research, specifically the study of endothelial seeding and the pathogenesis of abdominal aortic aneurysms (AAA).
- Donald M. Lloyd-Jones, MD ScM, Department of Preventive Medicine: Dr. Lloyd-Jones’ interests lie primarily in preventive cardiology, particularly investigating lifetime risk factors for various cardiovascular diseases and the factors that modify those risks.
- Mark K. Eskandari, MD, Division of Vascular Surgery, Department of Surgery: Dr. Eskandari’s primary research interests include the application of minimally invasive endoluminal technology for the treatment of vascular disease, including therapies for carotid artery disease, aortic aneurysms, and aortic dissections. Dr. Eskandari has been actively involved in numerous clinical research trials assessing the results of carotid artery stenting and comparing them to endarterectomy for stroke prevention.
- Jane L. Holl, MD, MPH, Department of Pediatrics: Some of Dr. Holl’s research interests include patient safety, the role of chronic stress in premature labor, the contribution of clinician and system factors to clinician-initiated deliveries, the prevalence and severity of food allergies, and health services.
- Karl Y. Bilimoria, MD, Division of Surgical Oncology, Department of Surgery: Dr. Bilimoria’s work is at the forefront ofquality improvementresearch and focuses onsurgical risk adjustment, risk assessment, and risk stratificationas well as the study ofefficiency measures such as reoperation, length of stay, and readmission.
- Joseph M. Feinglass, PhD, Division of General Medicine, Department of Medicine: Dr. Feinglass’ research focuses on health services in the areas of arthritis, peripheral vascular disease, healthcare quality, medical informatics, health disparities, policy, and economics.
- Mary M. McDermott, MD, Division of General Medicine, Department of Medicine: Dr. McDermott is a leading authority on functional impairment and functional decline in persons with lower extremity PAD. Her research interests include the comprehensive care of adults, peripheral vascular disease, and preventative medicine.
- Andrew W. Hoel, MD, Division of Vascular Surgery, Department of Surgery: Dr. Hoel’s research interests focus on patient-reported measures to improve clinical decision making and on patient care strategies to improve post-operative outcomes. He is actively involved in research collaborations evaluating quality of life in patients with aortic aneurysms, in effective communication about high-stakes clinical decision making and in smoking cessation after vascular surgery to improve clinical outcomes.
- Matthew R. Glucksberg, PhD, Department of Biomedical Engineering: Dr. Glucksberg’s research interests include pulmonary mechanics and lung liquid transport, blood pressure and flow in the retinal circulation, and noninvasive sensing of blood flow and analytes.
- Timothy J. Carroll, PhD, Department of Biomedical Engineering: Dr. Carroll’s research interests include MRI, stroke, perfusion, and angiography. He currently is investigating time resolved MRA of intracranial vasculature.
- David M. Mahvi, MD, Division of Surgical Oncology, Department of Surgery: Dr. Mahvi has extensive experience in device development and testing.
- Samuel I. Stupp, PhD, Department of Materials Science and Engineering: Dr. Stupp is an interdisciplinary scientist whose research combines chemistry, materials science and medicine, including nanostructures, nanofibers, bone, peptides, self-assembly, and amphiphiles.
- C. Shad Thaxton, MD, PhD, Department of Urology: Dr. Thaxton’s research interests are atherosclerosis, bioengineering, cancer biology, nanotechnology and radiology.
- Guillermo A. Ameer, ScD, Department of Biomedical Engineering; Division of Vascular Surgery, Department of Surgery: Dr. Ameer’s clinical interests include bioartificial organ systems, cell delivery and transplantation, and tissue engineering.
The applicants should contact the T32 coordinator for an application:
Jan Goldstein, T32 Coordinator
676 N. Saint Clair Street, Suite 650
Chicago, IL 60611
William H. Pearce, MD, Program Director
Jan Goldstein, T32 Coordinator
676 N. Saint Clair Street, Suite 650
Chicago, IL 60611
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