(2017-2019) - MENTOR: Jason Wertheim, MD
Vascular disease—including narrowing and occlusion of blood vessels that deliver oxygen and nutrients to the heart, vital organs and extremities—inflicts a significant public health burden for which improved methodologies to model disease, develop therapeutics, and design new interventions to alleviate disease may provide symptomatic relief and improve function. Dr. Hekman's project focuses on overcoming a major limitation in the development of patient-derived endothelial cells using induced pluripotent stem cell technology. This technology is currently limited by reprogramming-induced senescence whereby the mature cellular phenotype degenerates and is lost. She will work to overcome this barrier to generate functional patient-derived endothelial cells for clinical and therapeutic applications. She is a post-doctoral fellow supported by an F32 Ruth L. Kirschstein NRSA individual post-doctoral fellowship award from NHLBI.
Mansukhani NA, Yoon DY, Hekman KE, Hoel AW, Rodriguez HE, Pearce WH, Eskandari MK, Tomita TM. Outcomes in Obese Patients after Mesenteric Revascularization for Chronic Mesenteric Ischemia. Manuscript submitted to the Annals of Vascular Surgery.
Hekman KE, Michel E, Hoel AW. Groin Surgical Site Infection Reduction Initiative. Oral presentation, Vascular Quality Initiative Meeting, San Diego, CA, May 30, 2017.
Hekman KE. Case presentation. 41st Annual Northwestern Vascular Symposium, Chicago, IL, December 8-10, 2016.